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Perhaps the quintessential self contained one-handed food, the Twinkie is not only packed with sugar but also preservatives, so that it will actually survive long-term storage, making it a great emergency food for folks needing to tweet in war zones or for social media managers at major geek technology companies having to work late nights.
Other Hostess cakes such as the Ding Dong (or the appropriately-named "Yodel") may be substituted, but we strongly reccomend not consuming snacks which are chocolate covered when attempting to Tweet.
Originally we were going to go with the double-folded pizza slice as used by John Travolta in Saturday Night Fever since one could conceivably hold it in one hand while operating a virtual or full-size keyboard.
However the calzone is actually much more suited for single-handed use and is less likely to drip. Filled with mozzarella and ricotta cheese as well as meats such as pepperoni and ham, and available in both baked and deep fried variants, the Calzone is the clear winner in
Roman tweeting foods.