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Closing apps with a swipe-up gesture
If you want to close an app, instead of holding the icon with your finger, which before would make it "jiggle" and red Xs appear, you simply swipe up and the app closes.
Spotlight search not in the usual place
Spotlight is no longer out of sight to the very left of the stream of apps on the home screen. Pulling up from the bottom brings up the Control Center (see later), and swiping down from the bottom displays notifications. But that gap in between — basically where the apps are — you have to pull down. It's hidden above the top row of apps. Like a Windows 8-like learning experience, one hopes that Apple will make this a little more apparent somehow.
Spotlight now a swipe-down from anywhere above the dock
But when you get to Spotlight, it sports a Gaussian blur background on top of the home screen icons. When entering text, it lists everything it can find, from contacts to email, events, and calendar entries, even applications. Wherever possible — such as if Facebook is connected and updates contact pictures — it will display a small picture associated with that person. But, failing that, it defaults to the first two initials of that person, making it far easier to spot from the crowd.