The Enterprise Command Centre will be Dell's first for the South Asia region, which includes Australia, New Zealand, Malaysia, Singapore, India and Indonesia.
The centre will provide 24-hour support for Dell enterprise server and storage customers. It will also track customer issues in real-time, and provide service parts.
Dell customers in Australia previously had their service calls taken by staff in Malaysia or Australia, according to a Dell spokesperson.
Dell's other centres are in Japan, China, the United States, and Ireland.
Dell chief executive officer Kevin Rollins and Asia Pacific president Steve Felice will formally open the Enterprise Command Centre (ECC) in Penang on Thursday.