As a Front End Web Developer, I intersect that shady space betwixt the worlds of designer and developer. I build websites; I am an engineeer with visual proclivities.
On the gritty front line of contract work, clients are now demanding Responsive Web Design and experience with grids, and a good thing too. There is some disquiet over “hard coding” the grid column widths into the HTML itself (as with the deservedly popular 960 grid system by Nathan Smith), although there are workarounds and alternatives like Semantic.gs that use CSS preprocessors to calculate tricky column widths for you.
The biggest obstacle I have found, though, is a dumb-headed adherence to the grid, where designers have forced elements to fit the grid, rather than easing off the pedal and letting the design find it’s own way. So when I saw this saying blu-tacked up in a window, it had a special resonance:
Swap rules for grids and you have a good, er, rule of thumb.
Don’t let grids rule your life, let them guide your life.