iSoft's Australia and New Zealand managing director, Denis Tebbutt, will be leaving the company, with its NZ country manager James Rice to move into the leadership role.
"Denis will be leaving the organisation," the company said in a statement. "James Rice has been put into the leadership position for the Australian and New Zealand business unit."
The company did not reveal the reasons for Tebbutt's departure.
The move follows recent changes in iSoft including chief executive officer Gary Cohen who stepped down as chairman, and head of business development Steve Garrington who resigned his position on the board earlier this month. Both have maintained their executive positions within the company.
The company's stock price has also struggled due to uncertainty in the European and United Kingdom markets where the company conducts a good portion of its business.
The company laid off between 25 and 30 Australian employees earlier this year as part of a restructure.
Updated at 3:56pm: corrected to note that Gary Cohen has resigned as chairman of the iSoft board but has not resigned from the board.