Scrybe is Flash and it sets a new bar for web applications
As Marshall notes, somewhat humorously, Scrybe is done in Flash. Aside from the technology and the attention to detail, people across the blogosphere were struck by how great the application looked. People were enamored with the application because it was technologically revolutionary and it looked like a great user experience. Part of the reason it was able to achieve a great user experience is because it wasn't restricted by a browser.
The browser continues to be a gateway to the web, and it always will be. But Scrybe shows what's possible when you stop trying build applications based on HTML and JavaScript and really embrace Rich Internet Application technologies. Because it's based on Flash, Scrybe is usable by people on Windows, OSX and Linux meaning that it has all of the ubiquity of any other web application. But with RIAs, you can start from scratch making sure your application follows all of the usability rules that you think are important. You aren't restricted by the usability rules of the browser because you have a blank canvas. In the wrong hands, this can be dangerous. But when you give that power to an application like Scrybe, some great things happen.
People are starting to get it - Rich Internet Applications enable a new kind of experience for users. One that transcends both the web and the desktop by creating the next evolution. You don't want to have to worry about whether you are online or offline, you just want your data and you want to get to work. RIAs like Scrybe give you that functionality wrapped in a very sophisticated user experience. As a business, if you can give your users that kind of flexibility, you've already won half the battle.