Queensland Minister for Science, IT, Innovation and the Arts Ros Bates has resigned from her post, tendering her resignation to premier Campbell Newman on Friday.
Newman accepted her resignation, and said that she had done "an outstanding job under difficult circumstances".
"Unfortunately, the demanding role has taken a toll personally and on her health, and she had decided not to risk those issues impacting on the performance of her duties," he said in a statement.
"I commend her for her decision. She has done the right thing by her family, her constituents, and the government."
Bates had to announce several tough decisions by the state government during her tenure, including the axing of 400 IT workers. She was also at the centre of controversial claims that she was accepting payments from Technology One in return for meeting with the company.
Her health has also been in the spotlight, when, at the end of last year, she suffered injuries due to a fall at home. At the time, she was admitted to hospital, missing the last sitting of parliament for the year.
Education Minister John-Paul Langbroek will take up Bates' portfolio while the Newman government decides upon who will replace Bates.