ie8 fix

Take the CRP in my blood down, or the new statin dance

By | November 10, 2008, 7:35am PST

Summary: Many people with low cholesterol have heart attacks anyway, and a drug trial known as JUPITER, bankrolled by a statin maker, found that reducing CRP levels actually cut risks of a stroke or other other coronary event by half.

C-reactive protein from WikimediaTurns out statins are not just about the cholesterol count.

It’s also about a protein called C-reactive Protein or CRP. (Right, sport. The CRP in your blood.)

It’s a common protein in plasma, and it deals with inflammation throughout the body. (CRP illustration from Wikimedia.)

Many people with low cholesterol have heart attacks anyway, and a drug trial known as JUPITER, bankrolled by a statin maker, found that reducing CRP levels actually cut risks of a stroke or other other coronary event by half.

The 17,802 people studied were in middle-age, had LDL levels under 130, and a high-sensitivity CRP level of 2.0 mg. per liter or more. Half got the statin, in this case Crestor or rosuvastatin, half got a placebo. The study was due to last five years.

JUPITER was stopped after one year because the numbers were so stark and it was concluded that withholding the statin from the placebo group was ethically unfair.

The study leader, Dr. Paul Ridker, wrote that if this screening and treatment regimen became normal practice it could save 250,000 lives per year.

The NEJM is now soliciting comments, through November 26, from physicians on whether these results will change their practice.

You can demand the change yourself by using this simple request. Check the CRP in my blood and take it down, doc. It’s the new statin dance that’s going to be sweeping the country clubs.

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Disclosure

Dana Blankenhorn

Dana Blankenhorn has been a journalist, writer and part-time futurist for over 30 years. At the present moment I run only a personal blog in addition to my ZDNet open source blog. DanaBlankenhorn.Com has the subtitle The War Against Oil. In the past I have used it to write about political history, e-commerce, personal matters, some ideas related to open source, and The World of Always On, which is the idea of using sensors, motes and RFID to turn WiFi links into platforms for applications which live in the air. My IRA account at Schwab holds a few tech shares, most notably some Intel and Applied Materials, but there are no open source companies in it. I don’t even own any CBS stock.

Biography

Dana Blankenhorn

Dana Blankenhorn has been a business journalist since 1978, and has covered technology since 1982. He launched the Interactive Age Daily, the first daily coverage of the Internet to launch with a magazine, in September 1994.
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that is some heavy stuff there.
Been_Done_Before 10th Nov 2008
There must of been significant numbers for them to cease a study in action and declare it needed.

I wish they continued regardless. This doesnt account for long term affects of the drugs.

Regardless of my concern.. i do find it interesting.
0 Votes
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Quick response. Thank you.
Anton Philidor 10th Nov 2008
There's already resistance to the study findings.

The study considered the presence of irritation, and not the cholesterol level itself. People with acceptable cholesterol levels do have heart attacks and strokes.

So this study supports the contention that irritation is far more significant than cholesterol as a predictor/cause. So cholesterol may lose its place as a public enemy.


Also, lifestyle changes were not a significant part of the treatment with statins. The Doctor-controlled life was implicitly found ineffective.


So what this study does is identify a cause for deadly diseases and cure it. Doctors in their disappointment that the result was not the one favored have been rushing to deny what is being reported to them.

This is an issue to watch closely. The Doctor who sentences you to a diet of overcooked brussels sprouts and sends you to be contorted by bone-breaking machines may also be denying you the treatment which could prevent a damaging, perhaps fatal disease.
0 Votes
+ -
that is some heavy stuff there.
Been_Done_Before 10th Nov 2008
There must of been significant numbers for them to cease a study in action and declare it needed.

I wish they continued regardless. This doesnt account for long term affects of the drugs.

Regardless of my concern.. i do find it interesting.

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