ie8 fix

The diabetes trial failure

By | February 8, 2008, 6:42am PST

Summary: New studies involving enzymes, proteins and genes may well yield new clues as to how the diabetes progresses and how to deal with it. So this “failure” actually represents an enormous opportunity for the research community.

Type 2 Diabetes diagram from WebMDThe “failure” of a major diabetes study has reporters and their sources wringing their hands.

This should not be. (The picture is from the WebMD’s doctors’ site, medicinenet.)

Science often makes wrong turns, especially when it’s applied in the form of engineering or products.

The most notorious example was the advice given President Eisenhower in the 1950s, after his heart attack, to disdain butter in favor of margarine. Later we learned margarine is filled with trans-fatty acids, which are even worse for you than butter.

Oops.

If this, and the recent cholesterol studies, tell us anything it should be that common diseases are more complex than we think, that there is no magic bullet, no single variable whose control yields a certain cure.

Your cholesterol number, by itself, is not a predictor of heart disease. Your blood sugar number, by itself, is not a predictor of damage from diabetes.

In the case of heart disease we’re learning that the enzymes and proteins which dispose of cholesterol may be keys to understanding how the conditions of plaque can occur.

But it may be other things are involved as well, such as the conditions of the blood vessels that cause plaque to deposit on them.

In the case of diabetes, new studies involving enzymes, proteins and genes may well yield new clues as to how the disease progresses and how to deal with it.

So this “failure” actually represents an enormous opportunity for the research community. Anyone whose study was rejected because, the funders said, the problem has been solved should be taking another look.

Thus it’s the study that delivers “bad” news which may be far more important than one that delivers”good” news, in the long run. Because it’s the former you can learn from.

Now how do we get this word through the lips of the popular press?

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Disclosure

Dana Blankenhorn

Dana Blankenhorn has been a journalist, writer and part-time futurist for over 30 years. At the present moment I run only a personal blog in addition to my ZDNet open source blog. DanaBlankenhorn.Com has the subtitle The War Against Oil. In the past I have used it to write about political history, e-commerce, personal matters, some ideas related to open source, and The World of Always On, which is the idea of using sensors, motes and RFID to turn WiFi links into platforms for applications which live in the air. My IRA account at Schwab holds a few tech shares, most notably some Intel and Applied Materials, but there are no open source companies in it. I don’t even own any CBS stock.

Biography

Dana Blankenhorn

Dana Blankenhorn has been a business journalist since 1978, and has covered technology since 1982. He launched the Interactive Age Daily, the first daily coverage of the Internet to launch with a magazine, in September 1994.
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Without failure?
hgeorgescu@... 15th Feb 2008
The name of science without failure is monotheistic religion.
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The voice of reason
power_unit@... 8th Feb 2008
Thank you for not saying aiming for tight control is a bad thing. Most of us long-termers shoot for sub-6 regardless of the risks. The risks of not doing so are too high. I know first hand.

I agree that the medical researchers need to examine what happens when BG levels drop. There are many of us who are convinced that such drops can lead to eye hemmhorraging; we've experienced it. Though opthamologists all over seem to discount this assertion. Regardless of what they believe, it does happen and it happens a lot. This study is similar enough to make my spidy senses tingle. Big drops in BG levels kill people, but drugs and hypoglycemia have been ruled out already. Hmmm.

This study could very well be a landmark case. I just hope that all those diabetics with mediocre levels of control don't sit back and be happy about it. So you don't die right away? What's the point of living when you're blind, legless, and hooked to a dialysis machine three days a week? Then you die shortly after. Pffft!
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That's science
John L. Ries 8th Feb 2008
Scientific research has never been infallible. People working in good faith sometimes make mistakes and even when conclusions appear to be warranted by the evidence, additional research may require different conclusions. If the results of an experiment are not what the researcher expects, hypotheses may have to be revised or abandoned, but nobody need be embarrassed; it's just the nature of the game.
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My very point...
DanaBlankenhorn 9th Feb 2008
Now, how do we get the general population to understand this, accept this, and support the process?
And he even admitted it. Science and invention, which medical research is a small part of, are filled with massive numbers of failures with occasional leaps of success.

Most people do tasks every day that we all know work because we do them over and over again and get the same result. Science is about finding out things because we don't know how they work.

This diabetes study is based on a theory that if controlling each individual part of what influences diabetes, then if we try to radically reduce all of these negatives at the same time, we might be able to drastically reduce diabetes in a person.

So they designed the study to test it.

And surprise! People's bodies don't work the way we expected them to; and in a pretty big way too.

So they discontinued the attempts to radically drop BG, and are analyzing the data to figure out why it doesn't work.

Then they will modify their working model, and build another study to test the new model.

Rinse and repeat as necessary until they do get it right.

Of course if some no-minds get Mike Huckabee elected, you can expect hard science to go out the window while we test the power of prayer to cure all your ills.
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Without failure?
hgeorgescu@... 15th Feb 2008
The name of science without failure is monotheistic religion.

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