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Once you've created a Fluid Grid layout you can add page elements, using DIVs to wrap and group elements. Using Dreamweaver's Live view you can choose which screen resolution you're working in, and then place DIVs appropriately. Some may be in different places and in different sizes for different views, while some may be hidden. It's best to start with the mobile layout first, before working on desktop and tablet views.
If you're building mobile web applications, Dreamweaver CS6's JQuery mobile support simplifies building pages that work across the ever-growing field of mobile devices. Mobile apps need no longer all look the same, as you can now use Fireworks to design mobile swatches that can be used to apply styles to JQuery Mobile applications. Select the element you want to style, pick a swatch and apply.
Adobe recently purchased Nitobi, the developers behind the PhoneGap tools that wrap web applications as native mobile apps. That means that the PhoneGap Build cloud service is now part of Dreamweaver. Sign up for an account and you can upload content to the service, downloading mobile apps ready for testing and for the app stores. There's even the option of getting a QR code for an app, which you can use to load test devices or to share prototype downloads with clients.