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Deploy* is a free open-source web application that allows designers to select the name of a project, and through a series of radio buttons, you can select the Doctype, whether you want a CSS reset or jQuery integration, and it creates a zipped, ready-to-use package with all specified files and folders. Deploy* saves time and organizes your code's parent folders and more.
Blueprint is a CSS framework that uses a grid-like system including pre-defined typography, and includes a set of plug-ins, form styles, print styles, templates, and much more. The site offers great support including live demos, a Wiki, forums and discussion groups, a repository, and bug tracker. The zip file download is just under 4MB. However, it is not a silver bullet, and it's best suited for websites where each page may require its own design. Take a look at existing blueprint pages before deciding if the framework is right for you. You may also check out the test files in the tests directory, which demonstrates most of the features in Blueprint.