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With wires trailing all over your desk, you will soon be overcome with wire-madness. It's one of the many reasons why I try and keep my working-from-home office desk as clutter-free as possible by taking advantage of wireless technology. From a wireless Apple keyboard and a wireless Apple Trackpad (I use a Mac, if that didn't give the game away), and wireless headphones, it saves on a lot of hassle.
But for the necessary wires, you can keep them fixed and out of the way. These small adhesive pads clip wires in place on your desk, and keep unsightly cables out of sight or in a fixed location. Again, it's one of those things you will probably never notice again, but something you will never be able to live without.