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Those who like Twitter should immediately install Spaz HD. This beta app makes it fun to work with Twitter timelines and keep up with friends. The multiple column display is configurable and works just as well in portrait as it does in landscape orientation. It is very full-featured for a free app.
The TouchPad is a wonderful device for watching video with the large screen and smooth streaming. I admit I am a fan of watching video podcasts and network reruns when I have free time, and now that I use Video Flood HD that is so easy to do. The app aggregates online video from a lot of sources and presents them in an easy to use interface that has you watching the latest episode of your favorite show in no time. It plays the video from all sources right in the app which makes it very convenient to use. $1.99
I listen to audio on the TouchPad a lot, and I especially like finding new radio stations from around the world that capture my fancy. TuneIn is a free app that makes it simple to find radio stations by type or genre of music played, and fully supports user station presets for future use. TuneIn is my favorite way to listen to live talk radio on the TouchPad. Free