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Cracking open the HTC ThunderBolt was tricky but not overly difficult. It uses standard Phillips screws, which are easily accessable. Unfortunately, there's not much to do inside the case once you get there.
The ThunderBolt appears to be designed for easily assembly, not repair. Nearly all the internal components are soldered to the main PCB. For all practical purposes, the display/digitizer assembly is a single unit. And components, such as the speakers are actually embedded into the device's covers.
Photo by: Bill Detwiler / TechRepublic
Caption by: Bill Detwiler