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This variation on the standard QWERTY keyboard is intended for people with vision problems. This is the Keys-U-See model from The Key Connection.
IBM has developed Shark, an advanced pen-based shorthand method that allows users to input words into mobile devices by tracing them letter by letter on a virtual keyboard. Pictured is the shorthand for the word "layout" on a QWERTY keyboard.
Ergodex DX1 Input System
Some designs don't even look much like a keyboard. The Ergodex DX1 Input System, which is primarily aimed at game enthusiasts, includes a pad, a removable tray, 25 numbered keys with a storage tray, preprinted labels, an installation CD and a quick-start guide.