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Campus: Redwood Shores, Calif.
What happened: Oracle, then a $584 million software company, set up shop in Redwood Shores in 1989. Its glass towers became a Silicon Valley landmark as Oracle went on to become the second-largest software company in the world. But even Oracle wasn't immune to the office curse: In 1990, the company had its first-ever money-losing quarter and was forced to lay off hundreds.