Cutting this material was fairly simple with wood-cutting and drilling tools. Just be careful to slow down on the table saw so you don’t chip the polycarbonate. I had initially avoided putting in vent holes in the back but the CPU fan and the PSU fan dynamically ramped up in RPM because of the increasing temperature and caused some noise. Once the 4 holes were put in the back, the CPU fan stayed at lower RPM and remained fairly silent even if I stress loaded the CPUs.
For more details, see George Ou's blog post