At my company, I use Salesforce.com for my front office (Sales & Service teams), and Microsoft Dynamics GP (formerly Great Plains for my backoffice).
The difference of the ease of use, ability to customize and configure, and maintain both applications is the difference between night and day.
When the Microsoft CRM Salesman comes calling, I'm ready. Show me first how to make Microsoft Dynamics GP as easy to use as SFDC, and then I'll consider adopting Microsoft CRM Online.
If you give me a product that saves $$$, but gives me more headaches -- like the daily headaches I get from wrestling with "Great Pains" -- I'm flat out not interested.
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