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Back in the '60s, I was a summer intern at Litton in Minneapolis. Under the assumption that the heart must pulse for a reason, we proved in the lab that pulse flow provides more efficient mass transfer across a membrane. (The same principle applies to energy transfer.) A pulseless heart, I would think, will be less efficient than the alternative, and could possibly put needless stress on the lungs and related systems. We applied for NIH funding. I don't know if follow-up research was conducted, as I graduated and went on to work in a different field, but we devised mathematical models that were included in the proposal to NIH, and that ought to be available from somebody's file. Unfortunately my personal copy of the proposal was lost when my basement flooded several years ago.
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