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If you keep on top of best practices and patches, no.

CobraA1 21st Apr 2009

If you keep on top of best practices and the latest security practices, no.

The vast majority of these infections come from three sources:

-The machines off in the corner that are forgotten and are still running some ancient OS that isn't supported anymore.

-People who just don't get the whole idea that if you get software from a morally questionable website or an unknown email, chances are the software you get is gonna also be questionable.

-People who turn off their security features. Whether it's because they think they "know better" or because "it's annoying," they're leaving themselves at risk.

If, however, you keep your PC up to date and follow basic security practices - no, you should not be scared. My PC hasn't had any major trouble for years.