What happens when viruses use vulnerabilities inside of whitelisted applications to tunnel past your firewall and a/v? They already do it with IE and svchost frequently.
One needs a virus scanner with strong "heuristic" scanning which uses algorithms to detect malware "in the wild". Best one I know of is Nod32 from Eset.
Unlike definition based scanners you don't need to wait for the a/v company to analyse the virus before they can catch it. (and yes, keep those firewalls running)
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