ROI is certainly one of the issues when selecting a Cloud based solution. For SaaS solutions specifically, there are also a number of other factors to consider. While the theoretical ROI may be great, if the other capabilities required are not there then the adoption of the SaaS solution will not succeed.
There is a nice discussion of some of these factors at:
http://www.virtusa.com/blog/index.php/2010/05/10-factors-to-consider-when-selecting-saas-solutions/
Marrying ROI with these factors will help ensure the overall success when selecting a SaaS solution.
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