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About the only time I connect the cable to my iPhone is when it's charging, and given the frankly pathetic battery life, this is something I'm doing a lot.
Please Apple, add wireless charging to the iPhone. This would be so cool, and open up the way for awesome accessories such as an in-car charging cradle where I wouldn’t have to futz about plugging in the cable each time I use it.
Apple, please bump up the highest capacity you offer to 128GB. I know it will be eye-wateringly expensive, but I carry around a lot of apps and data on my iPhone, and even 64GB is feeling a little cramped.
More robust construction
Along with a tougher screen, I'd like to see Apple make the whole iPhone a lot more robust. A number of companies are making their smartphones waterproof and dustproof, and this is certainly something that would appeal to users, especially considering how common a problem water damage is.