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More robust construction
Along with a tougher screen, I'd like to see Apple make the whole iPhone a lot more robust. A number of companies are making their smartphones waterproof and dustproof, and this is certainly something that would appeal to users, especially considering how common a problem water damage is.
While 802.11ac – also known as gigabit wi-fi, which is three times faster than 802.11n – wasn't ready for the iPhone 5s and iPhone 5c, we can expect that the new handset will support this standard.
The flipside of this is that faster wi-fi will put a heavier drain on the battery.