AMD's top-end, 3.4 GHz (4.0 GHz turbo), 16-core/32-thread is a behemoth.
The ASUS ROG Zenith Extreme sTR4 features the X399 chipset, and comes with support for 128GB of RAM, and the following expansion:
Why 64-gigabyte? Why not!
Nvidia's flagship GeForce GTX 1080 Ti is the most advanced gaming GPU ever created, powered by the new NVIDIA Pascal architecture, which means it's just the graphics cards to put into this build (yes, two! You could saved significantly on this build and fit just the one).
Price: 2 x $1,099
A super-fast SSD to put your operating system and other applications you want to load fast onto.
A secondary drive for your data, applications and other general storage needs.
This 1000W PSU offer plenty of overhead for overclocking and adding more components such as an additional GPU or more drives.
Does everything you could ever want from an optical drive.
What case you get is a very personal choice (and if this is something you're going to be looking at and working with for the next few years, it's sometimes worth investing in).
Personally, I like a case that is robust (flimsy cases are a pain), aren't filled with sharp metal shards that will rip at my flesh, and offer plenty of space for hardware.