Many potential drugs seem promising when they’re tested in cell cultures and animal models, but then fail during clinical trials because well, those tests are different from human tissue.
To build a think layer of human skeletal muscle, they start with a cartridge of specially prepared muscle cells. This is loaded into a 3-D printer, which then deposits them in uniform, closely spaced lines in a petri dish. This arrangement allows the cells to grow and interact until they form working muscle tissue that’s nearly indistinguishable from something you’d find in a real person.
Rather than use ink-jet printers to deposit cells, this technology lets cells interact with each other – like the way they do in the body. They’re packed together tightly and incubated, prompting them to trade chemical signals.
When they're printed, the cells are kept bunched together in a paste that helps them grow, migrate, and align themselves properly. (Muscle cells orient themselves in the same direction to create tissue that contracts.)
Take a look at a photo gallery of the process.
So far, Organovo has built tissue of several types, including cardiac muscle, lung, and blood vessels. They’ve only made small pieces of tissue, but the goal is to use their 3-D printer to make organs for transplants.
The company plans to fund its organ-printing research with revenue from printing tissues to aid drug development. It’s set up partnerships with major companies, starting with Pfizer.
From Technology Review.
Image: Organovo’s NovoGen MMX Bioprinter
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