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CryptKeeper works with Classic GNOME, Gnome 3, KDE, and XFCE.
LibreOffice doesn't actually contain true encryption, but it does allow you to digitally sign your documents and password protect them.
If you work with a lot of sensitive documents, I recommend you take advantage of LibreOffice's security features. They offer one of the easiest ways to protect documents created in the LibreOffice suite.