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In Mac OS X 10.6 (Snow Leopard), Apple integrated support for Microsoft Exchange into its built-in apps: Mail, iCal, and Address Book. Unfortunately, this required Exchange 2007 or later on the backend and the integration was a little buggy, but it was another step toward making Macs more friendly in the many businesses that are run on Microsoft software in the server room.
Photo credit: Apple
If you'd prefer to view this as a text-based list, see the companion blog post.