Are genetically modified mosquitoes coming to America?

To control dengue fever in Florida, a biotech may release mosquitoes engineered to produce offspring who die before the disease can spread.
Written by Janet Fang, Contributor on

To control dengue fever, one biotech has developed genetically modified mosquitoes whose offspring die before they can spread the disease.

These mosquitoes have already been released in Brazil, Malaysia, and the Cayman Islands. In Key West, Florida, the disease reappeared 3 years ago, after an absence of over 70 years.

And the US Food and Drug Administration is currently reviewing an application from the UK-based Oxitec. Florida residents are gathering names for a petition.
Nature News explains:

  1. Their mosquitoes (known as OX513A) are an engineered version of Aedes aegypti, the main transmitter of dengue fever, which infects at least 50 million people a year.
  2. The modified males carry a lethal gene kept in check only by a special diet.
  3. They survive to mate with wild females, but the offspring die.
  4. In field tests conducted in Juazeiro, Brazil, the engineered insects shrank the A. aegypti population in an 11-hectare area by 85% over a year.

The Florida Keys Mosquito Control District (FKMCD) in Stock Island is a taxpayer-funded operation that spends more than $1 million a year to control A. aegypti in Key West with insecticides.

In 2010, the FKMCD asked Oxitec if it would do a field trial with its mosquitoes in Key West. The next year, the company applied for FDA approval. A media report that very month suggested that officials were hoping for a mosquito release as early as January 2012, prompting concerns among residents.

The petition raises prospects of unintended consequences, such as the emergence of a deadlier dengue virus that gets around the absence of A. aegypti. And residents in Key West say they don’t want to be tested like “guinea pigs” and “I don’t want my family being used as laboratory rats for this.” Michael Specter writes in The New Yorker:

There is, of course, another theoretical catastrophe to consider: a dengue epidemic in Key West. So far the city has largely been spared, but the region, as Oxitec’s chief scientist Luke Alphey told me when I spoke with him for my article, is “living in a sea of dengue.”

When Oxitec opened up Moscamed, a mosquito-production facility, earlier this month in Juazerio, residents cheered. But the University of Sao Paula team engaged the community before seeking approval for their trial from Brazil’s agency for biotechnological safety, CTNBio.

[Via Nature, New Yorker]

Image: female Aedes aegypti / CDC

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