In all, there are eight remote code execution flaws, which can allow hackers to gain access to, or take control of an affected system without user prompts or permission.
With half of all the patches applying to the company's productivity suite — Office 2007 (Service Pack 3) and Office 2010 (Service Pack 1) are affected — users are advised to patch their systems as soon as possible. The latest Office 2013 release is not affected, however.
Internet Explorer 6 on Windows XP through to Internet Explorer 10 on Windows 8 and RT-based devices face another round of patches. Server-based versions of the browser are rated "moderate," but should still be patched sooner rather than later.
Last month, Microsoft pulled a number of Patch Tuesday updates after server-based Active Directory Federation Services (ADFS) stopped working. The patches were withdrawn after Windows Server 2008 and 2012 users complained.
Microsoft is also expected to issue a number of non-security related fixes to its Surface Pro and Surface RT tablets.
The security fixes will be released on September 10 through the usual update channels, such as Windows and Microsoft Update.
Correction at 1:30 p.m. ET: Updated end-of-support for Windows XP.