Now this is a tricky one to do, because you can never work entirely in the cloud. For my own levels of sanity, the only offline application I will use is Firefox, my web browser; I do use Foxmarks which enables me to get my bookmarks online, so I'll be keeping that in an open tab at all times. I won't be using anything else offline, that includes things like Windows Calculator, but any files I need to access I'll sync to the web using Live Mesh or upload directly to an online office application; Google Docs for example.
WIsh me luck... I'll need it. Feel free to leave comments in the live blog above or in the Talkbacksbelow.