The move is in order to "secure consistent profit," the Japanese technology giant said in a statement on Thursday.
The job cuts will be made in the current financial year, which are aimed to help cut costs by more than $184 million.
But one loss is another gain: Toshiba said it will ramp up its business-to-business (B2B) offering by expanding its product range — including workstations and tablets, and diversifying its business partners.
This is expected to grow B2B sales to over 50 percent in the fiscal year of 2016, it said.
A Toshiba spokesperson said that the U.S. consumer business will "remain intact" on both the consumer and enterprise side.
Toshiba makes PCs and tablets for a range of consumer and business customers, including Google's Chromebooks. However, it's not clear whether or not Chromebooks would be affected by the restructuring.
The electronics giant expects the PC restructuring to cut operating profit by about $415 million, but did not alter its earnings guidance for the current year.
Updated on September 19: with Toshiba spokesperson statement.