AMD's top-end, 3.4 GHz (4.0 GHz turbo), 16-core/32-thread is a behemoth.

• 16 cores / 32 threads
• 3.4 GHz base and 4.0 GHz precision boost clocks
• Socket sTR4
• DDR4 Support
• 8MB L2/32MB L3 cache
• 14nm Summit Ridge
• Support for 64 PCIe lanes
• Unlocked for overclocking

Price: $999

The ASUS ROG Zenith Extreme sTR4 features the X399 chipset, and comes with support for 128GB of RAM, and the following expansion:

• Extended ATX Form Factor
• AMD X399 Chipset
• AMD TR4 Socket
• 8 x DDR4-3200 (OC)
• 6 x SATA III, 3 x M.2, 1 x U.2
• 4 x PCIe 3.0 x16 Slots
• 1 x PCIe 2.0 x4 & 1 x PCIe 2.0 x1 Slots
• SupremeFX S1220 8-Channel HD Audio
• 802.11ac Wi-Fi & Bluetooth 4.1
• Nvidia SLI & AMD CrossFireX Support

Price: $550

Why 64-gigabyte? Why not!

• DDR4 2133 (PC4 17000)
• Timing 13-15-15-28
• CAS Latency 13
• Voltage 1.2V

Price: $570

Nvidia's flagship GeForce GTX 1080 Ti is the most advanced gaming GPU ever created, powered by the new NVIDIA Pascal architecture, which means it's just the graphics cards to put into this build (yes, two! You could saved significantly on this build and fit just the one).

• 11GB 352-Bit GDDR5X
• Core Clock 1480 MHz
• Boost Clock 1582 MHz
• 1 x HDMI 2.0 3 x DisplayPort 1.4
• 3584 CUDA Cores
• PCI Express 3.0 x16

Price: 2 x $1,099

A super-fast SSD to put your operating system and other applications you want to load fast onto.

• M.2 2280
• 512GB
• PCI-Express 3.0 x4
• Max sequential reads: Up to 3500 MBps
• Max sequential writes: Up to 2100 MBps

Price: $299

A secondary drive for your data, applications and other general storage needs.

• Interface: SATA 6.0Gb/s
• Capacity: 2TB
• RPM: 7200 RPM
• Cache: 64MB
• Improved Architectural Designs: Dual Core Processor, High Resolution Controller (HRC), StableTrac Technology
• Improved Data Protection: Vibration Control Technology (VCT), Corruption Protection Technology (CPT), NoTouch Ramp Load Technology
• Superior responsiveness with the next-generation speed that you need

Price: $125

This 1000W PSU offer plenty of overhead for overclocking and adding more components such as an additional GPU or more drives.

• ATX12V / EPS12V
• Full Modular
• 80 PLUS GOLD Certified
• 100 - 240 V 47 - 63 Hz
• +3.3V@25A, +5V@25A, +12V@83.3A, -12V@0.8A, +5VSB@3A

Price: $140

What case you get is a very personal choice (and if this is something you're going to be looking at and working with for the next few years, it's sometimes worth investing in).

Personally, I like a case that is robust (flimsy cases are a pain), aren't filled with sharp metal shards that will rip at my flesh, and offer plenty of space for hardware.

• Steel/Plastic/Tempered Glass ATX Mid Tower
• 2 x USB 3.0/Mic/Headphone front ports
• 6 x 3.5-inch/2.5-inch internal 3.5-inch drive bays

Price: $90